Abstract: It is well known that acupuncture is effective for treatment of gastric disease in human. We have observed the effect of acupuncturing point such as, Acupuncture Single Point Zhongwan, Neiguan (PC6), Zusanli (ST 36), on fluorohistochemical changes of G cells of antral mucosa in 42 patients with gastric disease. The results show that after acupuncture treatment the amount of fluorescent 6 cells and the fluorescent intensity of gastrin in the G cells were obviously decreased in patients with duodenal ulcer, as compared with that before acupuncture treatment. However, the amount of G cells was increased by acupuncture treatment in patients with chronic atrophic gastritis. These data indicate the acupuncture may regulate c cell from abnormal to normal condition in gastric mucosa of gastric disease.