What does acute transformation mean for myeloproliferative disorder?

Health Description
Health Consultation Description: Is acute transformation of a myeloproliferative disorder terminal?


Expert Reply

Condition analysis:
These two questions are only intended to be general. Is acute transformation of a myeloproliferative disorder ALWAYS terminal? If a 90 year-old nonambulant patient with diabetes, cadiomyopathy, COPD and a pleural effusion had an acute transformation of such a disorder then what would be the approximate life expectancy in days or months? I appreciate that the latter question would be difficult to answer even with an examination of the patient. Even a rough estimate would be helpful.

Instructions:
Stem Cell Transplantation: Patients with advanced MPN may qualify for a number of experimental therapies including stem cell transplantation. The only curative therapy for MPN (excluding chronic myelogenous leukemia) is allogeneic stem cell transplantation, which is the transfer of stem cells from one person to another.

There are several experimental studies open at UCSF Medical Center utilizing stem cell transplantation in patients with MPN. Whether stem cell transplantation is an appropriate therapy for an individual patient depends on a number of factors including age, MPN subtype, current symptoms or the extent of disease and the availability of a donor. People are encouraged to consult with a stem cell transplantation doctor to learn more about MPN, possible treatments and stem cell transplantation.



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