Diagnosis of Histiocytosis is still quite nonspecific because there could be many organs involved at one point. No amount of physical examinations can possibly trace the occurrence of this disease because all the symptoms can be associated with many other health conditions. Histiocytosis can only be singled out through x-ray of the bone, the entire skeleton, and the pulmonary tract, Bronchoscopy with biopsy, bone marrow and skin biopsy, complete blood count, and Pulmonary function tests.

Histiocytosis is mostly characterized by a punched-out tumor in the bones. No particular site has been singled out that is why a survey of the whole skeletal system is actually needed to provide a full view of the condition. Sometimes the tumor even occurs in the skull.

Proper diagnosis is very significant in such a rare disease as Histiocytosis. Medical updates occurring alongside the disease is needed for the research documents to deliver absolute answers to the physicians’ questions.