TCM treatment based on syndrome differentiation:
1. Deficiency of Heart and Spleen
Herbal Prescription: Radix Astragali (Huangqi), Radix Codonopsis (Dangshen), Rhizoma Atractylodis Macrocephalae (Baizhu), Semen Ziziphi Spinosae (Suanzaoren)">Semen Ziziphi Spinosae (Suanzaoren), Radix Angelicae Sinensis (Danggui), longan aril, Radix Rehmanniae Praeparata (Shudihuang), Radix Paeoniae Alba (Baishaoyao), Fructus Schisandrae (Wuweizi), Radix Glycyrrhizae (Gancao)

2. Deficiency of Both Qi and Blood
Herbal Prescription: Radix Codonopsis (Dangshen), Rhizoma Atractylodis Macrocephalae (Baizhu), Poria (Fuling), Radix Glycyrrhizae (Gancao), Radix Angelicae Sinensis (Danggui), Radix Rehmanniae Praeparata (Shudihuang), Radix Paeoniae Alba (Baishaoyao), Fructus Schisandrae (Wuweizi), Citrus aurantium (Chenpi), date

3. Deficiency of Spleen and Kidney
Herbal Prescription: Radix Codonopsis (Dangshen), Radix Astragali (Huangqi), Poria (Fuling), Rhizoma Atractylodis Macrocephalae (Baizhu), Radix Rehmanniae Praeparata (Shudihuang), Radix Paeoniae Alba (Baishaoyao), Liriope graminifoia (Maidong), Cortex Cinnamomi (Rougui), Herba Cistanchis (Roucongrong), Rhizoma Pinelliae (Banxia), Radix Glycyrrhizae (Gancao)

Western treatment
While treating MA, it is firstly necessary to determine the underlying factors responsible for vitamin B12 and/or folate deficiency. This helps to plan adequate long-term treatment of the disorder for patients.

Sufferers are given Vitamin B12 injections daily for 1 week, then on a weekly basis for 4 weeks, and finally on a monthly basis until the vitamin levels are stabilized. Patients having a continued deficiency risk should be regularly treated with their monthly injections. Some sufferers may also be treated with oral vitamin B12 pills. Oral folic acid pills can be administered for several months to cure Folic acid deficiency. Alcohol should be avoided by the patients while treatment is on. Psychiatric treatment accompanied by substance abuse counseling should be administered to the patients if necessary.