Churg-Strauss syndrome, also called allergic granulomatous angiitis, is a disease characterized by inflammation of the blood vessels in persons with a history of asthma or allergy. The symptoms of the Churg-Strauss syndrome include fatigue, weight loss, inflammation of the nasal passages inflamma, numbness, and weakness. The ultimate test for the diagnosis of Churg-Straus syndrome is a biopsy of involved tissue. Treatment of Churg-Strauss syndrome involves stopping inflammation and suppressing the immune system. The Churg-Straus syndrome is named for the American pathologists Jacob Churg and Lotte Straus. Suspicion of CSS is based on information including:

Medical history - to look for the presence of CSS symptoms, especially the presence of asthma, allergies and other features suggestive of disease.

Imaging tests such as x-rays, including computed tomography (CT), to see any abnormalities in areas such as the lungs or sinuses.

Physical examination - to detect sites of organ involvement and to exclude other illnesses that may have a similar appearance.

Blood tests - to look for abnormal blood counts with an increase in eosinophils.

Urinalysis - to detect excessive protein or the presence of red blood cells.

Once the diagnosis of CSS is suspected, a biopsy (tissue sample) is often performed to try to confirm the presence of eosinophils, eosinophilic granulomas and/or vasculitis. Biopsies of suspected organs or other disease sites are only recommended when abnormal findings are seen in the exam, laboratory tests, or imaging tests. Biopsies are not required in all cases.