The exact cause behind Polymyositis is not yet known. However, it falls in the category of auto-immune disease. It is also suspected to have some genetic links. Certain infections such as virus, parasites (protozoa), Lyme disease, etc. might trigger Polymyositis.

Recent studies indicated involvement of certain immunological parameter such as some cytokines (IFN-gamma) and IL 2, etc. which are released after microvascular muscle injury. That, in turn, lead to activation of some other cytokines such as TNF-alpha, which is also responsible for continued and recurring inflammation of the muscles. All in all, polymyositis is a multifactorial disorder, where genetic, immunological and other factors are involved. Homeopathic treatment tries to address multiple factors and bring about control of the disease processes as well relief in the symptoms.