Treatment of Pityriasis Rosea
Pityriasis rosea usually requires no treatment and resolves spontaneously. Treatment is not necessary if the rash does not cause significant symptoms. Typically, pityriasis rosea will usually clear on its own within six to nine weeks without medical intervention.

The most common symptom is itching, which can be treated with topical steroid creams (like hydrocortisone cream) and oral antihistamines (like diphenhydramine [Benadryl], cetirizine [Zyrtec]). These will not shorten the duration of the rash but will decrease the itching. Another treatment for itching is ultraviolet light (UVB) or sunlight. Generally, the best treatment is to avoid being overheated by reducing exercise and avoiding hot showers and baths.

There has been limited evidence of reduced duration of pityriasis rosea with the off-label use of the antibiotic erythromycin or off-label use of antiviral medications such as acyclovir (Zovirax) or famciclovir (Famvir). However, neither of these medications has been proven to be uniformly effective in the treatment of pityriasis rosea and they are not usually necessary or required.