Hypercalcemia of Multiple Myeloma
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Hypercalcemia is a condition in which you have too high a concentration of calcium in your blood. Calcium performs important functions, such as helping keep your bones healthy. However, too much of it can cause problems. Hypercalcemia makes it hard for calcium to carry out its normal functions.

What Are the Symptoms of Hypercalcemia?
You might not have any symptoms if you have mild hypercalcemia. If you have a more serious case, you might have symptoms that affect various parts of your body.

Kidneys: Symptoms related to your kidneys can lead to: excessive thirst, excessive urination, pain between your back and upper abdomen on one side.

Abdomen: Symptoms related to the abdomen include: nausea, abdominal pain, decreased appetite, Constipation, vomiting

Skeletal System: High calcium levels can also cause bone issues, including: bone pain, height loss, bowed shoulders, curvature of the spine, fractures from disease

What Causes Hypercalcemia?
Your body regulates the calcium level in your blood through the parathyroid hormone (PTH), and another hormone called calcitonin. Normally, PTH increases when the calcium level in your blood falls and decreases when your calcium level rises. Your body also makes calcitonin when your calcium level gets too high. When you have hypercalcemia, your body can’t regulate your calcium level as it normally would. There are several possible causes of this condition.

Hyperparathyroidism
The parathyroid glands are four small glands near the thyroid gland in the neck. They regulate parathyroid hormone, which in turn regulates calcium in the blood. Hyperparathyroidism occurs when one or more of your parathyroid glands becomes overly active. This is the leading cause of hypercalcemia, especially in women over 50 years old. It occurs when the glands release too much PTH.

Lung Diseases and Cancers
Granulomatous diseases, such as Tuberculosis, are lung diseases that can cause your vitamin D levels to rise. This causes more calcium absorption, which increases the calcium level in your blood. Some cancers, especially lung cancer, Breast Cancer, and blood cancers, can raise your risk for hypercalcemia.



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