Typically, the first signs of chronic renal insufficiency are an increased water consumption and an increased quantity of urine. Other signs are weight loss, a dull coat and an increasingly difficult appetite. As renal insufficiency progresses, the kidneys are unable to eliminate metabolic waste and clinical signs become worse: vomiting, loss of appetite, ulcers in the mouth area, halitosis, weakness and depression. Other consequences of chronic renal insufficiency are anemia and hypertension. Anemia can worsen the loss of appetite, weakness and depression. Hypertension can cause eye damage (sudden blindness), cerebrovascular accidents, and heart and kidney damage.