Diagnosis for Malignant Hyperthermia
Malignant hyperthermia is often discovered after a person is given anesthesia during surgery.

There may be a family history of malignant hyperthermia or unexplained death during anesthesia.

The person may have a fast and often irregular heart rate.

Tests for the condition may include:
Genetic testing to look for defects in the genes that are linked with the disease

Muscle biopsy
Urine myoglobin (muscle protein)

Blood clotting studies (PT, or prothombin time; PTT, or partial thrombloplastin time)

Blood chemistry panel, including CPK (creatinine phosphokinase, which is higher in the blood when muscle is destroyed during a bout of the illness)